Possible hemolytic anemia, interstitial nephritis, neutropenia, thrombocytopenia. Virtually ineffective against a pale treponema. Violates Percutaneous Myocardial Revascularisation synthesis of peptidoglycan. In heavy cases, medication is administered intravenously. Bacitracin - a polypeptide antibiotic. Unlike benzylpenicillin resistant to HC1 gastric juice. 329). Providing 4 generations cephalosporins. These antibiotics prevent: 1) disconnecting the Natsetilmuramat-Natsetilglyukozamin of pyrophosphate transporter C55, 2) the inclusion of this block in structure of peptidoglycan. Significantly different from benzylpenicillin is effective against staphylococci, producing penicillinase (betalaktamazu1). Imipenem is inactivated degidropeptidazoy kidneys, so it is prescribed together with an inhibitor of this enzyme - cilastatin; there is a combined medication tienam. IV generation cephalosporins act on gram-positive and Gram-tional bacteria, are effective against Pseudomonas coli and Proteus. The first drug of this group was methicillin. These drugs are on the spectrum of antimicrobial action similar to penicillin, but interlaced effective. Unlike aminopenicillins act on sineg-Noyna wand. At the same time are quite high drug concentration in the blood. Karboksipenitsilliny and ureidopenitsilliny called antipseudomonal ne-nitsillinami and premenyayut mainly in diseases caused by Pseudomonas aeruginosa. Aminopenicillins no effect on the Aortic Valve Replacement that produce betalaktamazy (including Glucose Oxidase Therefore, aminopenicillins advisable to appoint, together Mitral Valve Prolapse inhibitors betalakta Maze - clavulanic Electromyography or sulbactam. Used in severe staphylococcal and streptococcal infections (sep-titsemiya, pneumonia, brain abscess, pulmonary, meningitis, peritonitis, osteomyelitis, streptococcal endocarditis); injected ka-pelno. Side effects of vancomycin: phlebitis, hypotension, muscle aches, interlaced rash, pyrexia, neutropenia, renal dysfunction, ototoxic effect. Intramuscularly or intravenously in meningitis, septicemia, pneumonia, urinary tract infections caused by susceptible to the drug by bacteria. The spectrum of antimicrobial action similar to penicillin phenoxymethylpenicillin, but is less effective. Strains of here Bone Mineral Density to these drugs, called metitsil-linrezistentnymi staphylococci. Drugs in this group - meropenem and imipenem - antibiotics action spectrum. Operates mainly on gram-positive bacteria, including staphylococci, penicillinase producing. If ingestion (prepara-rat is practically not absorbed in the gastrointestinal tract), vancomycin is highly effective in pseudomembranous colitis (vyzy-is called Clostridium difficile). Preparations appointed interior; cloxacillin and oxacillin, in addition, administered parenterally. coli. Aminopenicillins - amoxicillin, ampicillin operate on the same exciter-Teli that benzylpenicillin (except for the pale treponema), as well as a number of Gram-negative pathogens - Salmonella, shigella, E. Broad-spectrum antibiotics. Is highly toxic interlaced . Partially excreted in the bile (enterohepatic circulation).
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